The Electrostatic Nature of C 3 d - Complement Receptor 2 Association 1

of April 30 , 2017 . This information is current as Receptor 2 Association The Electrostatic Nature of C 3 d - Complement

The electrostatic nature of C3d-complement receptor 2 association.

The association of complement component C3d with B or T cell complement receptor 2 (CR2 or CD21) is a link between innate and adaptive immunity. It has been recognized in experimental studies that the C3d-CR2 association is pH- and ionic strength-dependent. This led us to perform electrostatic calculations to obtain a theoretical understanding of the mechanism of C3d-CR2 association. We used th...

The Two Sides of Complement C3d: Evolution of Electrostatics in a Link between Innate and Adaptive Immunity

The interaction between complement fragment C3d and complement receptor 2 (CR2) is a key aspect of complement immune system activation, and is a component in a link between innate and adaptive immunities. The complement immune system is an ancient mechanism for defense, and can be found in species that have been on Earth for the last 600 million years. However, the link between the complement s...

Electrostatic Steering Accelerates C3d:CR2 Association

Electrostatic effects are ubiquitous in protein interactions and are found to be pervasive in the complement system as well. The interaction between complement fragment C3d and complement receptor 2 (CR2) has evolved to become a link between innate and adaptive immunity. Electrostatic interactions have been suggested to be the driving factor for the association of the C3d:CR2 complex. In this s...

Physicochemical Analysis of the Interaction between Epstein - Barr Virus Glycoprotein gp 350 and Complement Receptor 2 using AESOP ( Analysis of Electrostatic Similarities Of Proteins )

Epstein-Barr Virus (EBV) infects a large percentage of the world’s population and is responsible for infectious mononucleosis and, in rare cases, Burkitt’s lymphoma and nasopharyngeal carcinoma. EBV’s primary means of infection is the association of the viral surface glycoprotein gp350 with Complement Receptor 2 (CR2) of the immune system. Various mutagenesis studies have identified key residue...